the science behind magnificent 7

Exclusive to The Eternity Medicine Program

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Introduction

Relying on lowering blood sugar with medications or insulin will not improve one’s health, nor will it counteract the effects of diabetes.


In one large study, the Accord study, published in the NEJM in 2008, the 10,000 patients treated with blood sugar-lowering drugs or insulin were monitored for their risk of heart attacks, strokes, and death. The National Institute of Health (NIH) ended the study early because the medical intervention was leading to MORE deaths, heart attacks, and strokes.


Many conventional hypoglycemic drugs will actually increase insulin levels - Hyperinsulinemia and not hyperglycemia is what increases endothelial dysfunction and death.

Turning Off The Fat Switch

The first enzyme in fructose metabolism, fructokinase, consumes ATP while it metabolizes fructose. The process not only generates AMP but also activates AMPD and intracellular uric acid which accumulates damaging the mitochondria. Uric acid is a powerful biological signaling molecule and is recognized as a biomarker of metabolic syndrome.

Hibernating Squirrels, Bears, and the Fat Switch

During summer animals accumulate fat in preparation for winter and AMPD activity is high. During winter animals switch to burning the fat and AMPK activity is high.

Unfortunately, unlike animals in the wild and our hunter-gatherer forefathers, we are exposed to sugar, grains, and processed foods 24/7 365 days a year and never turn off our fat switch. When this happens, the individual loses control of their appetite, develops the Metabolic Syndrome characterized by insulin resistance and increased fat stores, and in addition to hunger has fatigue due to the loss of energy from reduced ATP production in the mitochondria. Eventually, the mitochondria decrease in number and we become "locked in" to our new weight. Our approach to breaking this deadlock is twofold: first to turn off the fat switch by increasing AMPK and second to repair mitochondrial biogenesis to restore energy production.


Our Magnificent 7 product has 4 natural substances that increase AMPK and 3 that increase mitochondrial biogenesis. When this is taken together with the Eternity Medicine program we can often reverse diabetes in a few weeks and also restore “insulin sensitivity” that will help you finally lose weight. (Reverse Diabesity)

Nutraceuticals that increase AMPK

1. Berberine, a natural plant alkaloid, has many health benefits and has been used in Indian and Chinese Medicine for more than 2,500 years.

  • Diabetes Reversal - An excellent therapy to help reverse diabetes including diabetic neuropathy, kidney disease, and cardiomyopathy:

    i. Berberine increases the major nutrient sensor AMPK
    ii. Berberine lowers blood sugar
    iii. Berberine decreases HbA1c
    iv. Berberine decreases postprandial glucose
    v. Berberine decreases glucose production in the liver
    vi. Berberine slows the digestion of carbohydrates
    vii. Berberine increases glycolysis - the breakdown of glucose inside cells
    viii. Berberine improves HOMA-IR by 50%
    ix. Berberine increases insulin sensitivity

    Note: Berberine is as effective as Metformin and also showed that it significantly lowered the chances of dying from Covid-19.
  • Weight Loss - Adults taking 500mg of berberine 3 times daily for 12 weeks easily lost on average 5 pounds.

    i. Berberine inhibits fat storage and lowers visceral fat.
    ii. Berberine reduces the size of fat cells and reduces their number.
    iii. Berberine increases adiponectin and helps normalize metabolic function.
    iv. Berberine enhances “brown fat” that burns energy instead of storing it.
    v. Berberine increases the number of beneficial bacteria in the gut.

  • Cardiovascular Health

    i. Berberine lowers LDL-cholesterol
    ii. Berberine lowers triglycerides (TG)
    iii. Berberine lowers blood pressure
    iv. Berberine lowers inflammation
    v. Berberine lowers HbA1c
    vi. Berberine lowers oxidative stress in the mitochondria
  • Cancer Inhibition

    i. Research shows Berberine leads to cell cycle arrest and apoptosis
    ii. Berberine reduces inflammation
    iii. Berberine helps regulate microRNAs
    iv. Berberine inhibits NF-KB (including P52)
    v. Berberine enhances chemotherapy

  • Enhanced Memory and Cognitive Function

    i. Berberine improves both memory and learning
    ii. Berberine has been found to improve a number of neurodegenerative disorders.

  • Anti-Aging Effects

    i. Like Metformin, Berberine improves heart health, hypertension, immune functions, low bone density, cognition, diabesity and provides cancer prevention as we age.

Why Berberine Is Better Than ANY Pharmaceutical?

Berberine is an herbal plant substance that surpasses all others! Forget about curcumin, ashwagandha, and epigallocatechin gallate, etc.!


This has 10 times the power.

It is a stunningly versatile plant substance, proven to have many useful pharmacological effects, including weight loss, glucose control, antimicrobial and antiviral activity (including anti-SARS-Cov-2 virus we’ve been hearing so much about), antitumor activity, and is a strong anti-inflammatory, even inhibiting chronic cocaine-induced sensitization!


Berberine is a naturally occurring plant alkaloid extracted from Turmeric trees, goldenseal (Hydrastis Canadensis) or orange-root, Coptis, European barberry, goldthread, Oregon grape, and Phellodendron (Cortex Phellodendri) or Huangbai.

Goldenseal

For thousands of years, berberine extracted from these plants has been used as part of Ayurvedic and Traditional Chinese Medicine and Native American healing. Interestingly, berberine is only potent when taken orally and not applied topically. In fact, it is toxic when applied externally.


Pharmacokinetics of berberine indicates that adipose tissue is its main target. Adipose tissue, especially belly fat, is a huge energy reserve organ. The excessive proliferation and differentiation of fat cells can lead to excessive fat accumulation in adipose tissue, resulting in obesity AND berberine switches off the “fat switch”! (the WHAT?) Yes, Professor Richard J. Johnson discovered a mechanism which has been called the fat switch. If it’s ON, you gain weight. If it’s OFF, you lose weight.

Leptin Resistance

But it gets worse: AMPD also leads to leptin resistance, one of the main initiators of over-eating! Leptin is a so-called “hunger hormone”, or appetite regulator, and it switches off the feeling of wanting to eat. Its opposite number is another hunger hormone called ghrelin, which makes you feel peckish!


Readers will readily see that leptin is the one we want! It lessens our appetite. But if leptin resistance sets in, the body stops listening. In other words, eating will still trigger leptin release but it’s ignored. You go on eating anyway, eating a LOT!

Leptin resistance is crucial to overeating and gluttony.

All this is reversed by generating AMPK, which displaces AMPD. Where do we get AMPK? There
are con artists selling it on Amazon already, as if all you had to do was swallow a few capsules and disregard your lifestyle. Not true.


But there are important natural ways to ramp up AMPK. Changing how you eat is the most important, true: eat less or don’t eat at all for set periods... Intermittent fasting as it is called. Keto dieting is effective too.


But there are herb substances too, which make the change for us. AND ONE OF THE MOST OUTSTANDING OF THESE IS Berberine! In fact, it works so well, it is just as effective as metformin, the main diabetes medication used by doctors.

Good For Diabetics

In a 2021 pilot study, berberine significantly decreased HbA1c levels in diabetic patients. It was, in fact, comparable to the effect of metformin, a widely-used oral hypoglycemic pharmaceutical agent.

Since 1986 numerous published investigations have confirmed the anti-diabetic activity of berberine and discovered various mechanisms, including the promotion of insulin secretion, the alleviation of insulin resistance, the inhibition of gluconeogenesis, the promotion of glucose uptake and glycolysis, the improvement of inflammation, the inhibition of several destructive enzymes, and the regulation of gut microbiota disorders.


Glycolysis means the breakdown of sugars and the ultimate depletion of fat deposits caused
by excess blood sugar.

It’s Not Just For Blood Sugar But Blood Fats Too

We’ve been battered by the cholesterol hoax for decades. The level is not important; the balance of different lipids could be.


Berberine can be used as an alternative treatment for patients who do not tolerate statins, because of its lipid-lowering effects. The findings of a 2021 review (meta-analysis) demonstrated that berberine alone can reduce dangerous triglycerides, total cholesterol, LDL cholesterol, fasting blood glucose, and HOMA-IR levels in patients with metabolic disorders (HOMA-IR or Homeostatic Model Assessment for Insulin Resistance is the best measure we have of insulin resistance).


Compared with berberine, metformin had little effect on lipid parameters.

Promotes Insulin Secretion
Several in vitro studies have shown that berberine can promote glucose-stimulated insulin secretion, which is clearly better than injecting it. It had a positive effect on pancreas size, islet cells (which secrete insulin), and pancreatic insulin secretion.


Another study found that berberine treatment for 8 weeks could significantly reduce fasting
blood glucose (FBG), which is something we want to keep as low as possible. Years ago, FBG was debated as the number one marker for how you would likely live.


Insulin Resistance
In fact, insulin resistance is one of THE markers for obesity, disorder metabolism. Insulin resistance means that no matter how much insulin the body releases—to combat blood sugar levels—it does no good. Insulin is supposed to lower blood sugar but as the individual continues to gorge on sugars and starches (which turn to sugars), the mechanism doesn’t work anymore.

Blood sugar rises and rises, out of control... BAM! That’s the definition of diabetes!

Berberine is a potent oral hypoglycemic agent with a modest beneficial effect on lipid metabolism. It is safe and the cost of treatment by Berberine is very low. It may serve as a new drug candidate in the treatment of Type II diabetes, according to the ABOVE REVIEW.


There is so much more to Berberine: it’s an anti-inflammatory, anti-cancer, and antiviral and works against HSV-1 (cold sores), cytomegalovirus (CMV), influenza A and B, coxsackie, herpes zoster (hence shingles and chickenpox), rotavirus and respiratory syncytial virus (RSV).

Other Nutraceuticals in magnificent 7 That Increase AMPK

Gynostemma Pentaphyllum is from the cucumber or gourd family and is widely used in Asia. Extracts of saponins from this plant increase AMPK and a wide range of health
benefits.


a. lowers blood sugar
b. anti-obesity effect and lowers visceral fat and fatty liver
c. lowers BMI and weight-lowers ht/waist ratio
d. lowers triglycerides and cholesterol
e. lowers anxiety
f. improves microbiome
g. neuroprotective function
h. increases longevity (upregulates sirtuins)

Epicatechin is a flavonoid from chocolate. A study in the American Journal of Clinical Nutrition found "ingesting 100 grams of dark chocolate resulted in a decrease in blood pressure and improved insulin sensitivity in healthy people.” Epicatechin also works by
increasing AMPK.


a. lowers blood sugar
b. stimulates fat burning
c. decreases appetite
d. lowers inflammation
e. lowers blood pressure
f. increases blood flow by increasing NO
g. inhibits angiogenesis and fat gain
h. protects against cancer
i. improves bone density
j. helps muscle growth
k. improves athletic endurance
l. reduces aging of the skin
m. helps build immunity
n. helps neurodegenerative disease
o. also increases mitochondrial biogenesis
p. increases longevity

Vitamin C (ascorbic acid) can lower uric acid and blocks mitochondrial oxidative stress
and tames the 'fat switch’. Vitamin C can block the effects of fructose to cause metabolic
syndrome.

a. lowers blood sugar throughout the day (and minimizes spikes in sugar)
b. lowers blood pressure
c. good antioxidant and is vital for the body's healing process
d. supports the synthesis of proteins for blood vessels
e. helps absorb and store iron
f. stimulated white blood cells and helps immunity
g. lowers the risk of cardiovascular disease
h. may have a role in the common cold and cancer prevention.
i. helps lower the risk of Covid-19

Alpha-lipoic acid (ALA) is an antioxidant found in many foods. It is important for mitochondrial health-acts as a heavy metal chelator and is an important cofactor for mitochondrial enzymes like AMPK. It is both fat and water-soluble.


a. lowers blood sugar and improves insulin resistance
b. powerful antioxidant and recycles CoQ10, Glutathione, Vit C, and E
c. Towers NF-kappa B and inflammation
d. increases mitochondrial biogenesis
e. helps detoxify the liver
f. ALA inhibits AMPK in the hypothalamus and decreases appetite
g. lowers the risk of cardiovascular disease
h. slows brain aging and wrinkling and improves immunity
i. helps decrease neuropathy caused by diabetes

Resveratrol is a natural product found in grapes, mulberries, wine, and peanuts. Induces mitochondrial biogenesis in endothelial cells throughout the body.


a. enhances insulin sensitivity (can be seen from a single glass of wine)
b. improves mitochondrial biogenesis
c. enhances effects of metformin
d. lowers blood pressure
e. lowers body weight
f. improves neurodegeneration in the brain
g. cardiovascular protection (French Paradox)
h. promotes longevity by activating on sirtuins 1-7